Hyperlipidaemia and severe hypertriglyceridaemia in pregnancy

Key content Lipid and triglyceride levels increase in pregnancy do not pose problems for most women. However, pregnancy-specific factors genetic aberrations, especially mutations, may result supraphysiological hypercholesterolaemia (HC) severe hypertriglyceridaemia (sHTG). HC sHTG are associated with complications pregnancy, including acute pancreatitis, hyperviscosity syndrome pre-eclampsia. Abnormally high of lipids triglycerides also affect fetal growth the onset gestational diabetes. The clinical presentation diagnosis varied. Management options include lifestyle dietary restriction/modification, omega-3, bile-acid sequestrants, fenofibrate, statins plasmapheresis. Learning objectives To understand physiological changes that occur how these modulated. appreciate importance HTG their effects on maternal morbidity mortality. various approaches to management multidisciplinary management. Ethical issues Should every woman be screened during pregnancy? How safe other treatments lipid disorders women very discouraged from getting pregnant?